The BRAIN (Brain research through advancing innovative technologies) initiative is a multifaceted, ambitious program launched by President Obama in April, 2013. At least five federal entities are involved, coordinated and spearheaded by the National Institutes of Health (NIH). Within the NIH, ten Institutes are actively involved. This is an enormous array of talent and resources, but it also presents a challenge for achieving optimal coordination and interaction. The NIH created a “council of councils” –the BRAIN Multi-Council Working Group–to inform and involve the ten participating institutes. Each institute has asked a member of its own Advisory Council to join this “council of councils”, and in addition there are five at-large members. Dr. Story Landis serves as one of these at-large members. Her experience as Director of NINDS, especially her roles in the NIH Blueprint for Neuroscience Research, has made her an invaluable member of the Working Group.